![]() ![]() This finding was perhaps a stimulus to the important work which led to the isolation and characterization 2 of the adrenal cortical hormone aldosterone.Īldosterone is present in relatively minute amounts in plasma (one one-hundredth of the concentration of hydrocortisone), but its great potency indicates that it plays a major role in regulating the amount of sodium and potassium in the body through its direct effect on the renal tubule it accelerates renal retention of sodium chloride and the elimination of potassium ions. However, in 1950 it was found 1 that steroidal extracts of urine from patients forming edema contained a material which was potent in promoting sodium retention and potassium excretion in adrenalectomized rats. Nonregulated aldosterone production may result from a single adrenal adenoma, bilateral adrenal hyperplasia, a mineralocorticoid producing adrenal carcinoma. It is essential for sodium conservation in the kidney, salivary glands, sweat glands, and colon. ![]() ![]() FOLLOWING demonstration of the remarkable biological effects of hydrocortisone, many investigators were willing to recognize this steroid as the major and totipotent hormone secreted by the adrenal cortex. Aldosterone is the main mineralocorticoid steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland. ![]()
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